Pkan hips-derived astrocytes show impairment of endosomal trafficking: a potential mechanism underlying iron accumulation

HIGHLIGHTS

  • who: Sonia Levi from the Vita-Salute San Raffaele University, Milan, Italy, Proteomics of Metabolism Unit, Division of Neuroscience, IRCCS San have published the paper: PKAN hiPS-Derived Astrocytes Show Impairment of Endosomal Trafficking: A Potential Mechanism Underlying Iron Accumulation, in the Journal: (JOURNAL)
  • what: The authors employed the activity-enriching marker SynaptoZip (Ferro et_al, 2017) to investigate constitutive exoendocytosis and vesicular dynamics in PKAN-derived astrocytes. The study showed that CoA and 4-PBA treatments were able to revert the pathological phenotype without any attempts to investigate the mechanism of actions of the two . . .

     

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