HIGHLIGHTS
- who: Leucine-rich-repeat-kinase and collaborators from the Life Sciences, University of Dundee, Dow Street, Dundee , EH, United Kingdom have published the article: PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR GTPase domain, in the Journal: (JOURNAL)
- what: The authors demonstrate that phosphorylation and activation of in HEK293 cells is blocked by PKC inhibitors including LXS-196 (Darovasertib) a compound that has entered clinical trials. The authors show multiple PKC isoforms phosphorylate and activate recombinant in a manner reversed by phosphatase treatment. This study provides new . . .
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