HIGHLIGHTS
- who: Bárbara G. de Freitas and collaborators from the (UNIVERSITY) have published the research work: PKC-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception, in the Journal: Toxins 2021, 13, x FOR PEER REVIEW of 19/03/2014
- what: The authors showed that a single systemic administration of crotalphine induces analgesia for 5 h in non-sensitized rats.
- how: Since the inhibition of MEK an up-stream MAPK kinase blocks PGE2 induced hyperalgesia the following experiments were conducted in naïve rats i.e. without sensitization to focus on the mechanism . . .
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