Pkm2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis

HIGHLIGHTS

• who: Le Ni from the Animals All animal procedures were approved by the Ethics Committee of Tongji University School of MedicineAll mice were on the C BL/, background and were kept under specific-pathogen-free (SPF) conditions with a, :, h light-dark cycle at , u00b1 , u00b0C and, % humidity. Cardiomyocyte-specific Pkm, conditional knockout (Pkm, cKO) mice were generated as described previously [50]. In brief, the mice with Pkm, gene exon , flanked by two loxP sites (Pkm2f/f) were purchased from the Jackson Laboratory (024048) and backcrossed to the C BL/, background for more than , generations before crossed . . .
  

   

  

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