Plaa mutations cause a lethal infantile epileptic encephalopathy by disrupting ubiquitin-mediated endolysosomal degradation of synaptic proteins

HIGHLIGHTS

• who: Emma A. Hall from the (UNIVERSITY) have published the Article: PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins, in the Journal: (JOURNAL)
• what: The authors demonstrate that PLAA is required for the Ub-mediated sorting of membrane_proteins from the early to late endosome, targeting them for lysosomal degradation. The authors demonstrate that PLAA is essential for neural function, through dual roles of_(1) regulating post-endocytic trafficking of signaling receptors necessary for neural development and_(2) directing sorting of synaptic vesicle (SV) components during recycling . . .
  

   

  

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