Plakophilin-2 haploinsufficiency causes calcium handling deficits and modulates the cardiac response towards stress

HIGHLIGHTS

  • who: Chantal J.M. van Opbergen et al. from the Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan, CM Utrecht, The Netherlands have published the research: Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress, in the Journal: (JOURNAL)
  • what: The authors first examined the protein levels of Ca2+ -handling-related proteins via western blot on ventricular lysates of three-month-old wildtype (WT) and PKP2-Hz mice .
  • how: In this study heterozygous PKP2 knock-out mice (PKP2-Hz) were used to . . .

     

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