HIGHLIGHTS
SUMMARY
Microglia represent the resident macrophagic cells of the brain and play a crucial role in the response to acute neurological injuries including traumatic brain injury, hemorrhage, and stroke. Prior studies of brain derived EVs have focused primarily on neuronal, astrocytic, or endothelial cell derived EVs whilst circulating microglia derived EVs (MEVs) have not been well described. EVs released from microglia bear the characteristic microglia proteins TMEM119 and Iba1, can be detected in the cerebrospinal fluid, and represent large contributors to the brain derived EV pool in healthy individuals. In the plasma assays of both . . .
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