HIGHLIGHTS
- who: The cientificWorldJOURNAL and collaborators from the Saarland University, Kirrbergerstraβe, Homburg/Saar, Germany have published the research work: Plasmalogens Inhibit APP Processing by Directly Affecting γ -Secretase Activity in Alzheimer’s Disease, in the Journal: (JOURNAL) of 10/Oct/2011
- how: As APP and its processing secretases are all integral_membrane_proteins the authors analyzed in this study whether plasmalogens major components of neuronal membranes influence amyloidogenic and nonamyloidogenic processing of APP. For determination of assay specificity the authors used γ-secretase Inhibitor X (50 μM) (Calbiochem Darmstadt Germany) (supplement Figure S3). To evaluate a potential effect of . . .
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