Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by arg253, lys256, and lys257 in the streptokinase β-domain and kringle 5 of the substrate*

HIGHLIGHTS

• who: Anthony C. Tharp from the (UNIVERSITY) have published the article: Plasminogen Substrate Recognition by the Streptokinase-Plasminogen Catalytic Complex Is Facilitated by Arg253, Lys256, and Lys257 in the Streptokinase β-Domain and Kringle 5 of the Substrate*, in the Journal: (JOURNAL) of July/17,/2009

SUMMARY

When bound to ␮Pm, SK assumes a highly ordered structure resembling a three-sided crater surrounding the catalytic_site that provides an exosite(s) for binding the catalytic domain of Pg as a substrate. In the first step of the SK-mediated Pg activation pathway, SK binds the . . .

 



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