Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation*

HIGHLIGHTS

• who: Terence F. McGuire from the CVLS( L) or the empty vector (pZIPneo) were maintained and plated in Dulbecco`s modified Eagle`s medium containing, % bovine calf serum and, % Pen-Strep (Life Technologies, Inc) and were kind gifts of Drs. Channing Der and Adrienne Cox (University of North Carolina, Chapel Hill, NC). Immunoblotting with Antiphosphotyrosine, Anti-MAPK, and AntiPDGF Receptor Antibodies-NIH- , cells transfected with the empty vector (pZIPneo) were plated (0.5-1., , cells/100-mm plate) on day , and then treated with inhibitors on days , and, . Inhibitor treatment on day , was accompanied by serum starvation . . .
  

   

  

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