HIGHLIGHTS
SUMMARY
Metastasis is a highly inefficient process with several rate-limiting_steps (Cameron et_al, 2000; Luzzi et_al, 1998). Due to enhanced cellular plasticity, metastatic cancer cells can often express developmental proteins that provide survival advantages (Ben-Porath et_al, 2008; Lawson et_al, 2015). Physiological functions of PTN include neuronal development (Landgraf et_al, 2008; Yanagisawa et_al, 2010), adipocyte differentiation (Gu et_al, 2007; Sevillano et_al, 2019), osteoclast development (Imai et_al, 1998), mammary epithelial_cell differentiation (Wellstein et_al, 1992), angiogenesis (Papadimitriou et_al, 2016), response to injury (Himburg et_al, 2010; Yeh et_al, 1998), and fetal lung development (Weng et_al, 2009; Weng and . . .
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