Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells

HIGHLIGHTS

• who: from the Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada, Ontario Institute for Cancer Research, Toronto, Ontario, Canada, Clinical have published the research work: Pluripotent Transcription Factors Possess Distinct Roles in Normal versus Transformed Human Stem Cells, in the Journal: (JOURNAL) of November/30,/2009
• what: Methodology/Principal Findings: Here the authors compare the role of Oct4 and Nanog two-core pluripotent TFs in transformed (t-hPSCs) and normal human pluripotent stem cells (hPSCs). While embryonic gene_expression patterns have recently been associated with malignancy , the authors provide evidence that Oct4 alone . . .
  

   

  

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