HIGHLIGHTS
- who: Gu00e9raldine Gentric from the Institut Research University rue d`Ulm, Paris, France have published the article: PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers, in the Journal: (JOURNAL)
- what: By studying pre-clinical models and cohorts of patients, the authors show that high-OXPHOS HGSOCs are highly sensitive to conventional chemotherapies and that chronic oxidative stress and PML play key roles in this chemosensitivity . The authors demonstrate here that PML and PGC-1a are both necessary for high-OXPHOS features. The authors show that high-OXPHOS ovarian cancer cells and tumor samples . . .
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