Polo-like kinase 4 (plk4) potentiates anoikis-resistance of p53ko mammary epithelial cells by inducing a hybrid emt phenotype

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• who: Irina Fonseca from the Centrosomes are the primary microtubule-organizing center (MTOC) of dividing animal cellsConsisting of two centrioles surrounded by a pericentriolar matrix (PCM), they participate in essential cellular processes, such as cell division, signaling, migration, and polarity [1, ]. Centriole biogenesis is tightly regulated and occurs once per cell cycle, in, phase, during which centrioles duplicate to ensure the assembly of a bipolar spindle in mitosis, an essential structure for proper chromosome segregation [2-5]. Polo-like kinase , (Plk4), is a regulator of centriole biogenesis that is required for centriole duplication [5-8] via the . . .
  

   

  

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