Poloxamer-based hydrogel as drug delivery system: how polymeric excipients influence the chemical-physical properties

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SUMMARY

    Tsol-gel and pH of P407 formulations with additives prepared in ultrapure water. A 5 mL transparent vial containing a magnetic bar and 3 mL of the preparation gel was placed in a water ice bath at 4 ◦ C. A digital thermosensor, with a sensitivity of 0.1 ◦ C (m) connected to a thermistor was immersed in the gel. In this configuration, a temperature variation lower than 0.5 ◦ C was observed in approximately 40 min in case of thermal gradient inside/outside the phantom of 22 ◦ C (i.e., temperature of the internal . . .

     

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