Polyamine-based nanostructures share polyamine transport mechanisms with native polyamines and their analogues: significance for polyamine-targeted therapy

HIGHLIGHTS

  • who: Cassandra E. Holbert and collaborators from the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Cancer Center have published the article: Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy, in the Journal: (JOURNAL)
  • what: This study describes the requirement of intact polyamine transport to uptake the newly synthesized nanopolyamines, Nano11047 and DSS-BEN. This study shows, however, that the nanopolyamines utilize the same polyamine transport machinery for entry into mammalian cells as do . . .

     

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