Polyamines and eif5a hypusination facilitate srebp2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection

HIGHLIGHTS

• who: Mason R. Firpo et al. from the Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Current address: University of Glasgow MRC-Center for virus research, Glasgow, United Kingdom have published the research: Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection, in the Journal: (JOURNAL) of April/18,/2023
• what: The authors report polyamines` involvement in translation through a process called hypusination promotes expression of cholesterol synthesis genes by supporting synthesis the master transcriptional regulator of cholesterol synthesis genes. This study provides . . .
  

   

  

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