HIGHLIGHTS
- who: Jorine M. Eeftens from the Princeton University have published the paper: Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show that PRC1 Polycomb subunits can facilitate the formation of multicomponent condensates, which can read and write repressive histone marks. Using the powerful spatiotemporal control of this system, the authors demonstrate that PRC1 condensation can induce chromatin compaction, but sustained phase separation is dispensable for maintenance of the compacted state.
- how: Despite the attractive simplicity of this . . .
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