Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis

HIGHLIGHTS

• who: Kosuke Hamahashi from the The experiments were performed under the approval and guidance of the Clinical Research Review Committee of Tokai University School of MedicineWe presented these preclinical research data to the MHLW in Japan and applied for a Class I regenerative medicine provision plan under the law for the safety of regenerative medicine. The permit was issued on April, and clinical research using PD sheets was allowed to begin. Informed consent was obtained from the parents or guardians of the donors in all cases. Some surgical specimens were irreversibly de-identified. All experiments handling human . . .
  

   

  

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