HIGHLIGHTS
SUMMARY
Consequently, in observational studies using electronic health record (EHR) data, a significant decline in eGFR might be a better measure of early kidney disease than a clinical diagnosis of ‘incident CKD` that requires albuminuria assessment. There are only a few published studies that report predictors and correlates of early eGFR decline in low risk adults (young and middle-aged adults with a low comorbidity burden i.e. low prevalence of diabetes_mellitus, hypertension, and cardiovascular disease). While most previous GWAS that evaluated renal phenotypes utilized cross-sectional eGFR or annualized slope of decline in eGFR . . .
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