Polygenic prediction via bayesian regression and continuous shrinkage priors

HIGHLIGHTS

• who: Tian Ge from the General Hospital M University have published the paper: Polygenic prediction via Bayesian regression and continuous shrinkage priors, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Although this approach has advantages in terms of computational and conceptual simplicity, and has been used to predict genetic liability across a broad phenotypic spectrum, recent studies have shown that this conventional method for PRS construction discards information and limits prediction accuracy4. The authors investigate a conceptually different class of priors-the continuous shrinkage priors. The authors investigate a specific g (known as the Strawderman . . .
  

   

  

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