Polymerogenic neuroserpin causes mitochondrial alterations and activates nfκb but not the upr in a neuronal model of neurodegeneration fenib

HIGHLIGHTS

• who: E. Du2019Acunto from the Department of Biology and Biotechnologies u2018Charles Darwinu2019, Sapienza University of Rome, Ple Aldo Moro, Rome, Italy have published the research: Polymerogenic neuroserpin causes mitochondrial alterations and activates NFu03baB but not the UPR in a neuronal model of neurodegeneration FENIB, in the Journal: (JOURNAL)
• what: The authors assessed distribution and found higher percentage of perinuclear localisation in G392E neurons particularly in those containing polymers phenotype that was enhanced by glutathione chelation and rescued by antioxidant molecules. membrane potential and contact sites between mitochondria and the were reduced in neurons expressing the . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.