HIGHLIGHTS
- who: MAPK and colleagues from the Tulane University, United States have published the research work: Polyploid giant cancer cells and cancer progression, in the Journal: (JOURNAL)
- what: The main reason is that large-sized cells are considered to be derived from repeated mitosis/cell division failure or genomic instability intermediates, and cannot maintain longterm survival and proliferation (Geigl et_al, 2008; Holland and Cleveland, 2009).
SUMMARY
PGCCs can be related to chemoresistance, tumor recurrence, and poor prognosis of solid cancer (Jia et_al, 2012; Zhang et_al, 2014a; Zhang et_al, 2015). For the same . . .
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