HIGHLIGHTS
- who: Johannes H. Proost from the (UNIVERSITY) have published the Article: Population Pharmacodynamic Modeling Using the Sigmoid Emax Model: Influence of Inter-individual Variability on the Steepness of the Concentration-Effect Relationship. a Simulation Study, in the Journal: (JOURNAL)
- what: It is the aim of this paper (procedure 1) to describe quantitatively the relationship between the steepness of the concentration-effect relationship and IIV in the model parameters, and_(procedure 2) to investigate whether IIV in the model parameters can be estimated by population analysis with data obtained from study designs as used in reported . . .
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