Population pharmacokinetics and dose optimization based on renal function of rivaroxaban in thai patients with non-valvular atrial fibrillation

HIGHLIGHTS

  • who: Noppaket Singkham et al. from the Division of Clinical Pharmacy, Department of Pharmaceutical Care, School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand have published the research: Population Pharmacokinetics and Dose Optimization Based on Renal Function of Rivaroxaban in Thai Patients with Non-Valvular Atrial Fibrillation, in the Journal: Pharmaceutics 2022, 14, 1744. of /2022/
  • what: This study developed a population PK model of rivaroxaban in Thai DOAC-eligible AF patients. In this investigation, rivaroxaban concentrations were determined indirectly using commercially available Anti-Xa assays (BIOPHENTM Heparin LRT) with validated specific rivaroxaban calibrators. 11 . . .

     

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