HIGHLIGHTS
- who: Nengwen Xia from the University of Cambridge, United Kingdom have published the paper: Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis, in the Journal: (JOURNAL)
- how: Previous studies have shown that STING induced autophagy is Atg5 and Atg16L1 dependent and the results showed that 2`3`cGAMP stimulated LC3 lipidation disappeared in both Atg5-/3D3/21 cells . The laser confocal microscopy results showed that the accumulations of LC3 puncta in 3D4/21 cells were greatly reduced in LIR4 or LIR5 mutant relative to wild_type pSTING. The data showed that it . . .
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