Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis

HIGHLIGHTS

• who: David Brand and collaborators from the DBA1/J male mice (Jackson Laboratory, Bar Harbor, ME, USA), weeks old, were infected with Pgingivalis for , days (, to, ) and immunized , days later (D30) with collagen II (CII) emulsified in either complete Freund's adjuvant (CFA) or incomplete Freund's adjuvant (IFA). Mice were sacrificed at baseline (D0), (before arthritis induction), (, days after arthritis induction), and , (, days after arthritis induction). All animal experiments were approved by the Institutional Animal Care and Use Committee of the University of Michigan (Ann Arbor, MI, USA) and conformed to ARRIVE guidelines for preclinical studies . . .
  

   

  

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