HIGHLIGHTS
- who: Rajesh Jaiprashad and collaborators from the Department of Chemistry, Georgetown University, Washington, DC, USA have published the article: Portability of a Small-Molecule Binding Site between Disordered Proteins, in the Journal: Biomolecules 2022, 1887 of /2022/
- what: The authors show that a minimal small-molecule binding sequence of eight contiguous residues derived from the Myc protein can be ported into a different disordered protein and recapitulate small-molecule binding activity in the new context. The authors use the previously reported 1RH-derivative, 34RH-which maintains the core structure of 1RH, while replacing an ethyl . . .
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