Positive allosteric modulation of the glucagon-like peptide-1 receptor by diverse electrophiles*

HIGHLIGHTS

• who: Ana B. Bueno from the (UNIVERSITY) have published the paper: Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles*, in the Journal: (JOURNAL) of May/13,/2016
• what: As an alternative approach, the studies were undertaken to investigate an allosteric mechanism for activation of GLP-1R.
• how: To determine whether these electrophilic GLP-1R modulators activate the receptor via a mechanism similar to BETP the compounds were tested in cAMP accumulation assays using cells expressing either wild-type or the C347A GLP-1R. Of these studies are presented . . .
  

   

  

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