Positive and negative allosteric modulators of the ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain*

HIGHLIGHTS

• who: Christophe Petrel from the (UNIVERSITY) have published the paper: Positive and Negative Allosteric Modulators of the Ca2+-sensing Receptor Interact within Overlapping but Not Identical Binding Sites in the Transmembrane Domain*, in the Journal: (JOURNAL) of January/22,/2004
• what: The authors report the calcimimetic properties of_(R)-2-[1-(1-naphthyl)ethylaminomethyl]-1H-indole (Calindol) (Fig 1), which also belongs to a novel structurally different series of calcimimetics . The authors have characterized a CaSR positive allosteric modulator, Calindol, which belongs to a novel chemically different family of molecules. This work has allowed the . . .
  

   

  

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