HIGHLIGHTS
SUMMARY
Preventing allergic disease, and alleviating constipation (Isolauri et_al, 2000; Aloisio et_al, 2012; Wang et_al, 2017b). The pathophysiology of constipation is quite complicated; the primary causes are inherent problems of colonic sensorimotor disturbances and pelvic floor dysfunction, whereas secondary causes are associated with medications, organic disease, and systemic disease (Andrews and Storr, 2011; Girirajan et_al, 2011). Several possible biological mechanisms of action are attributed to probiotics in relieving constipation conditions, including restoring the balance following intestinal dysbiosis, alternating gut sensation and modifying the function of metabolites, and regulating the intraluminal environment (Zhu et_al, 2014; Zhao . . .
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