Possible mechanism of metabolic and drug resistance with l-asparaginase therapy in childhood leukaemia

HIGHLIGHTS

• who: Ruizhi Zhou et al. from the Beihang University, China have published the paper: Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia, in the Journal: (JOURNAL)
• what: The study by Akahane et_al focused on the significance of SPI1 fusion in the methylation status of ASNS.
• future: There are limited cohort studies to refer to at present therefore additional larger cohort studies are needed to further confirm the possibility of ASNS promoter region methylation as a predictor of treatment response. Future studies focusing revealing the molecular mechanism of . . .
  

   

  

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