HIGHLIGHTS
SUMMARY
Increased neuroinflammation and neuronal cell loss are also prominent, particularly in the substantia nigra (SN) (Fearnley and Lees, 1991; Hardman et_al, 1996; Hirsch et_al, 2003). Currently, there are no treatments to halt or slow disease progression but deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) is highly effective at relieving motor symptoms in PD (Limousin et_al, 1995; Tagliati et_al, 2010; Limousin and Foltynie, 2019; Jakobs et_al, 2019). The irregular burst of neuronal firing in the STN in PD patients is destabilized by DBS (Bergman et_al, 1994; Remple et_al, 2011) but less is . . .
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