Post-translational modification-dependent oligomerization switch in regulation of global transcription and dna damage repair during genotoxic stress

HIGHLIGHTS

• What: Acetylation of AF9 strongly correlates with reduced interaction of AF9 with cognate interactors upon IR treatment For deeper understanding of this regulation of AF9 oligomerization and concomitant factor association, the authors focused on acetylation since an earlier high-throughput study showed acetylation of AF9 protein upon DNA damage caused by UV exposure28. For identifying the critical residue within AF9 that would be targeted for DNA-PKc-mediated phosphorylation, the authors focused on single S/TQ motif present at Serine 395 position within AF9. To address the role of unknown deacetylase(s) in this overall functional regulation . . .
  

   

  

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