Post-translational modifications in prp expand the conformational diversity of prions in vivo

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• who: Patricia Aguilar-Calvo from the (UNIVERSITY) have published the article: Post-translational modifications in PrP expand the conformational diversity of prions in vivo, in the Journal: (JOURNAL) of 08/03/2017
• what: The authors show that four prion strains serially passaged in GPI-anchorless mice led to fibrillar, angiocentric prions associated with a nearly identical clinical and pathological disease phenotype. The CPA comparison of the original and Post-GPI passaged ME7 strain showed no differences in the strain, whereas the authors report subtle differences in the biological readout (incubation period) and in the conformational . . .
  

   

  

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