HIGHLIGHTS
- who: Manuel Haas from the Division of Food Chemistry and Toxicology, Department of Chemistry, RPTU Kaiserslautern-Landau, Erwinu2011Schroedingeru2011Str52, Kaiserslautern, Germany have published the paper: Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery, in the Journal: (JOURNAL)
- what: The authors investigated the structure-dependent toxicity of up to 11 PAs in human HepG2-CYP3A4 cells and PHH, which are a gold standard in pharmaco-toxicokinetic in_vitro studies of the human liver. The study demonstrated that the ranking of PAs according to their cytotoxicity . . .
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