Potent and selective covalent inhibition of the papain-like protease from sars-cov-2

HIGHLIGHTS

• who: Brian C. Sanders from the Compounds were also tested against SARS-Co, variants using Vero , cells (obtained from ATCC) at the Institute for Antiviral Research at Utah State University under a service contract sponsored by NIAID using methods described previously Confluent or nearconfluent cell culture monolayers of Vero , cells were prepared in, well disposable microplates the day before testing. Cells were maintained in Modified Eagle Medium (MEM) supplemented with, % fetal bovine serum (FBS). For antiviral assays the same medium was used but with FBS reduced to, % and supplemented with , u00b5g/ml gentamicin. Compounds were dissolved in . . .
  

   

  

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