Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

HIGHLIGHTS

  • who: Rosaria Greco from the (UNIVERSITY) have published the research: Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine, in the Journal: (JOURNAL)
  • what: The aim of this study was to investigate the behavioral and biochemical effects of compounds ARN14633 and ARN14280 two URB597 analogs with improved solubility and bioavailability in a migraine-specific rat model in which is induced by nitroglycerin (NTG) administration. The authors focused on anti-hyperalgesic activity in the trigeminal area and on inhibition of the peptidergic and inflammatory response associated with . . .

     

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