HIGHLIGHTS
- who: Yijun Lin et al. from the NY, United States Nihon University, Japan have published the research: PPARu03b1: An emerging target of metabolic syndrome, neurodegenerative and cardiovascular diseases, in the Journal: (JOURNAL)
- what: As a transcription factor with fatty_acids to be the natural ligands, PPARa is a key TF in lipid metabolism.
- how: Clinical data showed that liver PPARa expression inversely correlates with NASH severity and importantly histological improvement is associated with an increase in expression of PPARa and its target genes .
SUMMARY
Overlap chromatin binding regions of LXR . . .
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