Ppfia4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through mthfd2

HIGHLIGHTS

  • who: Ru Zhao from the Department of Oncology, The First Affiliated Hospital of Shandong First Medical University have published the Article: PPFIA4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through MTHFD2, in the Journal: (JOURNAL)
  • what: The authors investigate the expression of the protein tyrosine phosphatase receptor type F polypeptide interacting protein alpha 4 (PPFIA4) using public datasets and tumor specimens from PCa cases by immunohistochemistry. The authors show that the increase of exacerbates aggressive phenotype resembling A fraction of localizes to mitochondria and interacts with a key enzyme for one-carbon metabolism . . .

     

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