Pr interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

HIGHLIGHTS

• who: Jessica van Setten from the Functional variants in significant lociWe annotated the , index SNPs and nearby SNPs in LD with the index SNPs (within , Mb and with r, >, ., in , Genomes Phase , CEU) and tested all non-synonymous SNPs with PolyPhen, and , to predict the functional implication. We performed an eQTL analysis using the , PR index SNPs. We examined eQTL associations from LAA and validated findings in tissue from right atrial appendage (RAA). For comparison, we also evaluated left ventricular tissue as well as peripheral whole blood. Human LAA tissue was obtained with consent from , European-American . . .
  

   

  

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