Pramipexole inhibits astrocytic nlrp3 inflammasome activation via drd3-dependent autophagy in a mouse model of parkinson⠒s disease

HIGHLIGHTS

• who: An-qi Dong from the Reagents and antibodies Pramipexole dihydrochloride (PPX, Tocris Bioscience, Bristol, UK) was purchased from Tocris BioscienceLPS (055:, Sigma, St. Louis, MO, USA), adenosine, ′-triphosphate (ATP, ), chloroquine (CQ, ), and all other reagents unless specified were purchased from Sigma-Aldrich. The sources of primary antibodies were listed as follows: anti-, (NB100-2220, NOVUS, Colorado, USA), anti-p, (P0068, Sigma, St. Louis, MO, USA), antityrosine hydroxylase (TH) (ab112, Abcam, Cambridge, UK) for Western blotting, anti-TH (T1299, Sigma, St. Louis, MO, USA) for immunohistochemistry study, anti-DAT (MAB369, Millipore, Darmstadt, Germany), anti-glial fibrillary acidic . . .
  

   

  

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