HIGHLIGHTS
- who: Mengwen Hu from the University of have published the research: PRC1-mediated epigenetic programming is required to generate the ovarian reserve, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors report molecular and genetic evidence that the PRC1 establishes repressive chromatin states in perinatal oocytes, defining a dedicated epigenetic program that directs the subsequent transition from MPI to dictyate arrest and formation of the ovarian reserve.
SUMMARY
How ovarian reserves are established and maintained remains poorly understood, in particular the roles of epigenetic mechanisms, which can generate long-lasting . . .
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