Prdm10 directs flcn expression in a novel disorder overlapping with birt-hogg-dubé syndrome and familial lipomatosis

HIGHLIGHTS

• who: Advance access publication date and collaborators from the UMC, Vrije Universiteit, Department of Human Genetics, Boelelaan, The , University of Groningen, University Medical Center Groningen, Department of Genetics, Hanzeplein, Groningen, The have published the paper: PRDM10 directs FLCN expression in a novel disorder overlapping with Birt-Hogg-Dubu00e9 syndrome and familial lipomatosis, in the Journal: (JOURNAL)
• what: The authors show that PRDM10Cys677Tyr loses affinity for a regulatory binding motif in the FLCN promoter abrogating cellular FLCN mRNA and protein levels. The authors propose that PRDM10 controls an extensive gene program and acts as a critical . . .
  

   

  

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