HIGHLIGHTS
- who: Corinne J. Smith and collaborators from the Purdue University Indianapolis have published the research: Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood, in the Journal: (JOURNAL)
- what: AAV NAbs enhance uptake of AAV vector into cDC and other blood phagocytes Consistent with previous studies, the blood donors in this study had a range of naturally occurring, pre-existing antibodies to AAV (Supplemental Table 1). More recent work has highlighted the role of innate immune system in response to AAV therapeutics further supported with . . .
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