HIGHLIGHTS
- who: from the (UNIVERSITY) have published the research: Precision Glycodendrimers for DCu2010SIGN Targeting**, in the Journal: (JOURNAL)
- what: The authors report the synthesis of compounds PM58,59 and the evaluation of their interaction with DC-SIGN by Surface Plasmon Resonance (SPR). The authors show that PM58,59 are effective at preventing DC-SIGN binding to SARSCoV-2 spike_protein and that, at 0.5 u03bcM, they block DC-SIGN mediated trans-infection by Ebola virus. The model uses pseudotyped recombinant vesicular stomatitis virus-luciferase (rVSV-luc) viral particles presenting the Ebola envelope glycoprotein (EBOV), and a . . .
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