HIGHLIGHTS
SUMMARY
ICB, such as PD-1 antibody, removes the inhibitory signal of effector T_cells by blocking the binding of inhibitory receptor (such as PD-1) on the surface of T_cells and inhibitory ligand (such as PD-L1) on the surface of tumor cells, enabling T_cells to kill tumor cells. ICB is usually only effective in hot tumors and is proven non-efficacious for cold tumors as ICB acts by removing the inhibitory signals from tumor infiltrating and residential effector T_cells that have been activated and then suppressed by tumor cells, but it would not work . . .
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