Precocious interleukin 21 expression in naive mice identifies a natural helper cell population in autoimmune disease

HIGHLIGHTS

• who: Elisabeth A. Marnik from the Bar Harbor, ME, USA Tufts University have published the research: Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease, in the Journal: (JOURNAL)
• what: Through use of an IL-21 fluorescence reporter mouse, the authors show that a significant population of CD4+ T_cells that are activated in the thymus and periphery soon after birth functionally express IL-21.
• how: Given the central role for BCL6 in directing antigen-induced TFH cells (Johnston et_al 2009 Nurieva et_al 2009 Yu et_al 2009 . . .
  

   

  

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