Prediction of designer-recombinases for dna editing with generative deep learning

HIGHLIGHTS

• who: Lukas Theo Schmitt from the (UNIVERSITY) have published the paper: Prediction of designer-recombinases for DNA editing with generative deep learning, in the Journal: (JOURNAL) of 14/Dec/2022
• what: The authors show that the resulting algorithm (RecGen), which the authors trained with 89 evolved recombinase libraries and their respective target sites, captures the affinities between the recombinase sequences and their respective DNA binding sequences. For the changes the authors focused on the half-site positions 7-12 because these strongly affect the activity of recombinases when they are changed43. The authors show that . . .
  

   

  

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