HIGHLIGHTS
- who: Isaac Omwenga from the Division of Toxicology, Wageningen University and Research, Stippeneng, WE Wageningen, The Netherlands have published the research: Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry, in the Journal: (JOURNAL)
- what: The authors aimed to assess whether in_vivo dose-dependent OP-induced AChE inhibition can be predicted by an animal-free approach. This study aims to develop a PBK model for profenofos in rats and humans and apply the models to predict dose-dependent in_vivo AChE inhibition . . .
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